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Updated: Jun 23, 2025

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Electrochemical synthesis of phosphorylated azaspiro[4.5]di/trienones through dearomative spirocyclization
Xiaocong Zhou1, Jian Wang1, Dumei Ma2
1Institute of Drug Discovery Technology, Ningbo University, Zhejiang, China. wuju@nbu.edu.cn.
Abstract:
Cp2Fe-mediated electrochemical synthesis of a diverse array of phosphorylated azaspiro[4.5]di/trienones has been developed, which demonstrated broad substrate scope and good diastereoselectivity. It represents the first example of electrochemical synthesis of phosphorylated azaspiro[4.5]di/trienones, circumventing the need for external oxidants and high temperatures. Moreover, a plausible mechanism including radical-initiated dearomative cyclization driven by ferrocenium cations has been provided, which was supported by the related mechanistic study.
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