Related Experiment Video
Updated: Jun 23, 2025
09:54
Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine
Published on: November 4, 2018
8.1K
Emerging mRNA Technology for Liver Disease Therapy.
Ji Wang1, Yile Fang1, Zhiqiang Luo2
1Department of Rheumatology and Immunology, Institute of Translational Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
ACS Nano
|June 25, 2024
Summary
Messenger RNA (mRNA) technology shows promise for treating liver diseases. This review explores advancements and challenges in using mRNA therapeutics for hepatic conditions.
Area of Science:
- Hepatology and Molecular Medicine
- Biotechnology and Pharmaceutical Sciences
Background:
- Liver diseases represent a significant global health burden, necessitating novel therapeutic approaches.
- Current treatments for hepatic diseases have limitations, driving the search for innovative solutions.
Purpose of the Study:
- To review the fundamentals of messenger RNA (mRNA) technology.
- To discuss various liver diseases, their etiologies, risk factors, and conventional treatments.
- To summarize recent progress in applying mRNA technology for liver disease therapy.
Main Methods:
- Literature review focusing on mRNA technology and its application in hepatology.
- Analysis of existing therapeutic strategies for liver diseases.
- Synthesis of current research on mRNA-based treatments for hepatic conditions.
Main Results:
- mRNA technology offers a promising platform for liver disease treatment.
- Specific mRNA-based systems targeting factors like HGF, HBV antibodies, and nuclear factors are under development.
- Various liver diseases, including those caused by genetic factors and viral infections, are being addressed.
Conclusions:
- mRNA therapeutics hold significant potential to revolutionize liver disease treatment.
- Overcoming technical challenges is crucial for the successful clinical translation of mRNA-based therapies.
- These innovative strategies offer new hope for patients suffering from hepatic diseases.
Related Concept Videos
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
02:15Experimental RNAi
6.1K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K
02:30siRNA - Small Interfering RNAs
16.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.7K