Related Experiment Video
Updated: Jun 23, 2025
07:28
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
40.7K
Healthcare Resource Utilization Associated with Intermittent Oral Corticosteroid Prescribing Patterns in Asthma.
Trung N Tran1, Heath Heatley2, Arnaud Bourdin3
1BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA.
Journal of Asthma and Allergy
|June 26, 2024
Summary
Frequent use of oral corticosteroids (OCS) for asthma increases healthcare resource utilization and costs. Better asthma management is crucial to reduce OCS reliance.
Area of Science:
- Respiratory Medicine
- Pharmacoeconomics
- Health Services Research
Background:
- Oral corticosteroid (OCS) use in asthma management is linked to significant healthcare resource utilization (HCRU) and costs.
- Limited research exists on the impact of intermittent OCS prescription patterns on HCRU and costs.
Purpose of the Study:
- To investigate the association between intermittent oral corticosteroid (OCS) prescribing patterns and healthcare resource utilization (HCRU) and costs in asthma patients.
- To compare HCRU and costs between patients using intermittent OCS and those not prescribed OCS.
Main Methods:
- A historical UK cohort study (2008-2019) analyzed primary care records linked to Hospital Episode Statistics.
- Patients (≥4 years) with asthma on intermittent OCS were categorized by prescribing frequency (one-off, less frequent, frequent).
- Matched 1:1 with non-OCS users to compare HCRU and associated costs.
Main Results:
- Intermittent OCS use was associated with higher non-respiratory HCRU (GP visits, hospital admissions, length of stay) and costs compared to non-OCS users.
- Frequent intermittent OCS prescribing patterns showed the highest rates of HCRU and costs.
- A dose-response relationship was observed, with highest costs in the frequent prescribing group.
Conclusions:
- Intermittent OCS use, particularly frequent patterns, significantly increases HCRU and associated healthcare expenditures.
- There is a need for improved asthma management strategies to minimize reliance on intermittent OCS in primary care.
Related Concept Videos
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
236
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
236
01:26COPD: Management Using Bronchodilators and Corticosteroids
194
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
194
01:23Inhaled Medications
250
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
250
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
01:17Drugs Used in Lower Respiratory Disorders: Overview
402
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
402
01:30Asthma-IV: Nursing Management
3.0K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
First, in...
3.0K