Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A G-Quadruplex-Activated Near-Infrared Chemiluminescent Probe for In Situ Hepatic Imaging of the Hepatitis C Virus Genome.

Angewandte Chemie (International ed. in English)·2026

Same author

Label-Free Electrochemical CRISPR Platform Gated by Allosteric Transcription Factors for Ultrasensitive Small-Molecule Detection.

Analytical chemistry·2026

Same author

Proximity-Induced Phosphatase-Recruiting DNA Feedback Switch for Self-Adaptive Modulation of Receptor Signaling and Cell Behavior.

Journal of the American Chemical Society·2026

Same author

Chemically modified nucleic acid nanodevices: molecular engineering for drug delivery, theranostics, biosensing and diagnostics.

Chemical communications (Cambridge, England)·2026

Same author

Targeting Integrin β3 in Endothelial Cells Attenuates Cardiac Fibrosis Through the Calcium-Calmodulin-Dependent Protein Kinase IIα- cAMP-Responsive Element Binding Protein 1 Signaling Axis in Pressure Overload-Induced Heart Failure.

Journal of the American Heart Association·2026

Same author

Programmable DNA-Based NIR-II Molecular Probes for Hepatotoxicity-Associated MicroRNA Imaging <i>In Vivo</i>.

Journal of the American Chemical Society·2026

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

Advances in Bioinspired Artificial System Enabling Biomarker-Driven Therapy.

Meixia Wang¹, Huan Zhong¹, Yangbing Li¹

¹State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|June 26, 2024

Summary

Bioinspired artificial systems (BAS) leverage molecular engineering for targeted drug delivery, enhancing therapeutic efficacy and safety. These smart systems autonomously respond to disease biomarkers, paving the way for advanced precision medicine.

Keywords:

Bioinspired artificial systems Biomarker Personalized medicine Prodrug

More Related Videos

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

Related Experiment Videos

Last Updated: Jun 22, 2026

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

Area of Science:

Biomolecular Engineering
Nanotechnology
Drug Delivery Systems

Background:

Traditional therapeutics face challenges like poor adherence and adverse effects.
Disease-specific biomarkers offer opportunities to optimize drug activity.
Bioinspired molecular engineering enhances therapeutic efficacy, specificity, and safety.

Purpose of the Study:

To provide a comprehensive overview of bioinspired artificial systems (BAS) for biomarker-driven therapy.
To examine the evolution from open-loop to closed-loop BAS.
To detail various BAS modalities and their in vivo applications.

Main Methods:

Review of recent advancements in bioinspired artificial systems.
Analysis of molecular engineering strategies for biomarker targeting.
Elucidation of operational principles for different BAS modalities.

Main Results:

BAS can be engineered to respond to disease-specific biomarkers for tailored therapeutic effects.
Transition from external-cue-dependent systems to autonomous, self-regulating closed-loop systems is highlighted.
Various BAS modalities, including prodrugs, smart delivery platforms, artificial cells, and synthetic cell therapies, show promise.

Conclusions:

Bioinspired artificial systems represent a significant advancement in precision medicine.
Ongoing development of programmable and customizable BAS will enhance therapeutic outcomes.
Future perspectives focus on overcoming challenges in BAS technology for broader clinical application.