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Updated: Jun 22, 2025

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

Published on: March 7, 2017

Pediatric-type diffuse low-grade gliomas.

Asthik Biswas¹, Harini R Rao², Matthias W Wagner^3,4

¹Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. asthikbiswas@gmail.com.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery

|June 26, 2024

Summary

This summary is machine-generated.

Pediatric-type diffuse low-grade gliomas (pDLGGs) differ from adult gliomas in key molecular and clinical aspects. Molecular analysis is vital for distinguishing these four pDLGG subtypes due to overlapping features.

Keywords:

Angiocentric glioma Diffuse astrocytoma Low-grade glioma MAPK pathway MRI MYB MYBL1 PLNTY Pediatric

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A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

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Published on: May 9, 2025

Area of Science:

Neuro-oncology
Pediatric Pathology
Molecular Diagnostics

Background:

The World Health Organization (WHO) CNS tumor classification distinguishes adult and pediatric gliomas.
Pediatric-type diffuse low-grade gliomas (pDLGGs) present unique molecular profiles, behaviors, and prognoses compared to adult gliomas.
Accurate diagnosis of pDLGGs is critical for effective treatment strategies.

Purpose of the Study:

To highlight the distinct nature of pediatric-type diffuse low-grade gliomas (pDLGGs).
To emphasize the importance of molecular alterations in pDLGGs for diagnosis and treatment.
To underscore the necessity of molecular analysis for differentiating the four pDLGG entities.

Main Methods:

Review of the 5th edition WHO CNS tumor classification.
Analysis of molecular characteristics differentiating pDLGGs from adult gliomas.
Comparison of histopathological and imaging features across pDLGG subtypes.

Main Results:

pDLGGs are recognized as a distinct group from adult gliomas.
Specific molecular alterations are key identifiers and therapeutic targets in pDLGGs.
Four distinct pDLGG entities exist, sharing diffuse growth and overlapping diagnostic characteristics.

Conclusions:

Molecular profiling is indispensable for accurate classification of pDLGGs.
Understanding pDLGG molecular landscape is crucial for personalized treatment and improved outcomes.
Differentiating pDLGG subtypes requires integrated histopathological, imaging, and molecular data.