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This study developed thermosensitive polymeric micelles for nasal risperidone delivery. The micelles showed promising thermosensitive behavior and drug release for effective nasal administration.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Nasal drug delivery offers a non-invasive route for systemic and local therapeutic effects.
  • Developing stable and effective formulations for nasal administration remains a challenge.
  • Risperidone, an antipsychotic, could benefit from advanced delivery systems for improved patient compliance and efficacy.

Purpose of the Study:

  • To engineer thermosensitive polymeric micelles for nasal delivery of risperidone.
  • To evaluate the thermosensitive properties and suitability of the micelles for nasal conditions.
  • To assess the in vitro drug release and permeation characteristics of the developed system.

Main Methods:

  • Utilized a Quality by Design (QbD) approach for risk assessment and formulation development.
  • Characterized polymeric micelle size, distribution, and thermosensitivity at ambient and physiological temperatures.
  • Investigated the impact of pH and viscosity on micelle properties.
  • Performed in vitro drug release and permeation studies under simulated nasal conditions.

Main Results:

  • Polymeric micelles demonstrated significant size reduction from 118.4 nm at ambient temperature to 20.47 nm at 36.5 °C, indicating thermosensitivity.
  • Micelle properties were largely unaffected by variations in pH and viscosity, confirming nasal applicability.
  • Formulations exhibited rapid, burst-like in vitro drug release.
  • High and quick drug permeation rates were observed under nasal conditions.

Conclusions:

  • Thermosensitive polymeric micelles are a viable advanced drug delivery system for nasal risperidone administration.
  • The QbD-based development process ensured the suitability of the system for nasal application.
  • The rapid release and permeation profiles suggest potential for enhanced therapeutic outcomes.