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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Peptic Ulcer Disease I: Introduction01:30

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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Chronic Inducible Urticaria.

Dorothea Ritzel1, Sabine Altrichter2

  • 1Department of Dermatology and Venerology, Kepler University Hospital, Urticaria Center of Excellence and Reference (UCARE), Linz, Austria.

Immunology and Allergy Clinics of North America
|June 27, 2024
PubMed
Summary
This summary is machine-generated.

Chronic inducible urticaria (CIndU) requires accurate diagnosis through trigger testing and patient outcomes. Current treatments are off-label, highlighting the need for new, disease-specific options for affected patients.

Keywords:
Cholinergic urticariaChronic inducible urticaria (CIndU)Chronic urticaria (CU)Cold urticariaPhysical urticariaPressure urticariaSolar urticariaSymptomatic dermographism

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Area of Science:

  • Dermatology
  • Allergology
  • Immunology

Background:

  • Chronic inducible urticaria (CIndU) presents as hives and/or angioedema triggered by specific stimuli.
  • Accurate diagnosis relies on detailed patient history, specific trigger testing, and patient-reported outcomes.
  • Current treatment guidelines for CIndU mirror those for chronic spontaneous urticaria, often involving off-label use.

Purpose of the Study:

  • To emphasize the diagnostic approaches for chronic inducible urticaria.
  • To highlight the unmet need for disease-specific treatments in CIndU.
  • To note the ongoing research and clinical trials for CIndU.

Main Methods:

  • Anamnesis-driven diagnostic approach.
  • Specific and standardized trigger testing where available.
  • Inclusion of patient-reported outcomes in assessment.

Main Results:

  • Diagnosis of CIndU necessitates a multi-faceted approach combining history and objective testing.
  • Existing treatment protocols are not specifically approved for CIndU, leading to off-label prescriptions.
  • Patients with CIndU frequently experience a significant disease burden.

Conclusions:

  • Accurate diagnosis of CIndU is crucial and involves specific testing and patient-reported outcomes.
  • There is a critical need for novel, CIndU-specific therapies.
  • Ongoing clinical trials offer hope for improved management of this condition.