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Related Experiment Video

Updated: Jun 22, 2025

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
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Bioinductive patch as an augmentation for rotator cuff repair, a systematic review and meta-analysis.

Jonathan R Warren1, El R Domingo-Johnson1, Amelia A Sorensen1

  • 1Department of Orthopedic Surgery, University of Missouri Kansas City, Kansas City, MO, USA.

Journal of Shoulder and Elbow Surgery
|June 28, 2024
PubMed
Summary

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The bioinductive collagen patch shows promise in reducing rotator cuff repair retears and improving shoulder function. While complications are similar to traditional repairs, further case-control studies are needed to confirm its role.

Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Rotator cuff tears (RCTs) are common, causing shoulder pain and dysfunction.
  • Surgical repair (RCR) can fail due to retearing or nonhealing.
  • Bioinductive collagen patches are a novel augmentation for RCR, but data are limited.

Purpose of the Study:

  • To evaluate the efficacy and safety of bioinductive collagen patches in RCR.
  • To compare outcomes of augmented RCR with historical data of traditional RCR.
  • To perform a meta-analysis of complication and retear rates.

Main Methods:

  • PRISMA-guided literature search of multiple databases.
  • Inclusion of 13 clinical trials on full and partial-thickness RCTs.
Keywords:
Bioinductive patchbovine patchcollagen patchreviewreview of the literaturerotator cuff patchrotator cuff repair

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  • Meta-analysis of patient-reported outcomes, tendon thickness, and complication/retear rates.

    • Main Results:

    • Significant improvements in shoulder scores and pain relief were observed.
    • Tendon thickness increased similarly to traditional RCR.
    • Retear rates were 8.3% (full-thickness) and 1.1% (partial-thickness); complication rates were 15.5% and 16.2%, respectively.

    Conclusions:

    • Bioinductive patches are safe augmentations for RCR, improving outcomes and potentially reducing retears.
    • Further case-control studies are necessary to define the patch's role versus traditional RCR.
    • The patch may mitigate retear risk, a long-standing concern in rotator cuff repair.