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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Connective Tissue Disease Associated Interstitial Lung Disease

Scott M Matson1, M Kristen Demoruelle2

  • 1Division of Pulmonary, Critical Care and Sleep Medicine, University of Kansas School of Medicine, 3901 Rainbow boulevard, Mailstop 3007, Kansas City, KS 66160, USA.

Rheumatic Diseases Clinics of North America
|June 28, 2024
PubMed

Connective tissue disease associated interstitial lung disease (CTD-ILD) is a heterogenous collection of conditions with a diverse spectrum of interstitial lung disease (ILD) manifestations. Currently, clinical practice of lung-directed immunosuppression in CTD-ILD is supported by several randomized, placebo-controlled trials (RCTs) in patients with scleroderma and several observational, retrospective studies in other autoimmune conditions. However, given the harm of immunosuppression in idiopathic pulmonary fibrosis, there is an urgent need for RCTs of immunosuppression and antifibrotic agents in fibrotic CTD-ILD populations as well as the study of intervention in patients with subclinical CTD-ILD.

Keywords:
AntifibroticAutoimmunityConnective tissue diseaseImmunosuppressionInterstitial lung diseaseSubclinical interstitial lung disease

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