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Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
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Genetic polymorphisms associated with developmental defects of enamel: A systematic review
Aluhê Lopes-Fatturi1, Gabriela Fonseca-Souza2, Leticia Maira Wambier3
1Herrero University, Curitiba, Brazil.
International Journal of Paediatric Dentistry
|July 1, 2024
Summary
Genetic variations in enamel development genes are linked to developmental defects of enamel (DDE). This review confirms significant associations between specific gene polymorphisms and conditions like molar-incisor hypomineralization and dental fluorosis.
Area of Science:
- Genetics
- Developmental Biology
- Dental Research
Background:
- Genetic factors influencing enamel formation and mineralization are implicated in developmental defects of enamel (DDE).
- Understanding these genetic links is crucial for addressing DDE prevalence.
Purpose of the Study:
- To systematically review and evaluate existing literature on genetic polymorphisms associated with DDE.
- To identify specific genes and polymorphisms linked to various DDE manifestations.
Main Methods:
- A comprehensive systematic review of observational studies was conducted.
- Literature searches included major databases (PubMed, Scopus, Web of Science) and gray literature.
- Risk of bias was assessed using the Newcastle-Ottawa Scale.
Main Results:
- 28 studies met inclusion criteria, with 5 showing low risk of bias.
- Ninety-two genes involved in enamel development, morphogenesis, immunity, and hormone pathways were analyzed.
- Significant associations were found between polymorphisms in enamel development genes and molar-incisor hypomineralization (MIH), hypomineralization of primary second molars (HPSM), and dental fluorosis (DF).
- Hypoplasia was linked to polymorphisms in intronic regions.
Conclusions:
- Developmental defects of enamel, including MIH, HPSM, and DF, have a complex etiology significantly influenced by genetic polymorphisms.
- Specific gene polymorphisms are demonstrably associated with these dental anomalies.
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