THE IMPACT OF DIAMIDE DERIVATIVES OF OXALIC ACID ON FREE RADICAL LIPID OXIDATION IN WHITE RAT BRAIN AND LIVER.

Area of Science:

• Pharmacology
• Biochemistry
• Medicinal Chemistry

Background:

• Antioxidants are crucial for managing oxidative stress by neutralizing harmful free radicals.
• Uncontrolled free radical activity can damage cellular structures, including DNA and membranes.
• Oxidative stress is implicated in various diseases, necessitating the development of new therapeutic agents.

Purpose of the Study:

• To evaluate the antioxidant activity of novel oxalic acid diamide compounds.
• To assess the efficacy of these compounds in protecting brain and liver tissues.
• To determine the pharmacological potential of these synthesized molecules.

Main Methods:

• In vivo and in vitro experiments were conducted on white male rats.
• Brain and liver tissues were homogenized and analyzed for antioxidant activity.
• Physicochemical properties of the compounds were assessed using Lipinski's rule of five.

Main Results:

• All tested oxalic acid diamide compounds exhibited significant antioxidant activity (AOA).
• Compound SV-425 demonstrated the most potent antioxidant effects in both brain and liver tissues.
• Compound SV-427 showed the least antioxidant activity among the series.
• All compounds adhered to Lipinski's rule of five, indicating favorable drug-like properties.

Conclusions:

• The synthesized oxalic acid diamides possess notable antioxidant properties.
• These compounds can protect cells from oxidative stress, particularly in brain and liver tissues.
• The findings support the potential of these compounds for preventing and treating diseases linked to elevated free radical levels.