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MORTALITY RISK ASSESSMENT AMONG PATIENTS, HOSPITALIZED FOR COVID-19

L Beselia1, M Tsintsadze1, I Sakvarelidze2

  • 11David Aghmashenebeli University of Georgia, Tbilisi, Georgia.

Georgian Medical News
|July 4, 2024
PubMed

Insights

Severe COVID-19 outcomes in chronically ill patients are influenced by age and medical conditions. Key mortality predictors include sepsis, mechanical ventilation, and inflammatory markers, highlighting the need for further research.

Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Epidemiology

Background:

  • Georgia reported over 1.8 million COVID-19 cases with 17,132 deaths.
  • Insufficient data exists on risk factors for mortality in severe COVID-19.
  • Chronic medical conditions are associated with critical COVID-19 illness.

Purpose of the Study:

  • To evaluate clinical features of severe COVID-19 in chronically ill patients.
  • To determine prognostic factors influencing outcomes in intensive care unit (ICU) patients.
  • To identify predictors of mortality in this vulnerable population.

Main Methods:

  • Retrospective study of 250 chronically ill COVID-19 patients admitted to the ICU.
  • Patients divided into survivor and non-survivor groups.
  • Analysis of demographic data, comorbidities, and various clinical/laboratory characteristics (ultrasound, ECG, CT, blood markers).

Main Results:

  • Factors decreasing survival chance included elevated C-reactive protein (CRP), hydrothorax, sepsis/septic shock, high white blood cell (WBC) count, and mechanical lung ventilation.
  • Increased survival chance was associated with higher partial pressure of oxygen (pO2).
  • Mortality predictors identified: coagulation characteristics, inflammatory markers, sepsis, and mechanical ventilation.

Conclusions:

  • Chronically ill patients in the ICU with COVID-19 face decreased survival chances due to specific clinical and laboratory factors.
  • Sepsis, mechanical ventilation, and inflammatory markers are significant predictors of mortality.
  • Further research into COVID-19 mortality risk factors is crucial for pandemic preparedness.

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