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Implications of inflammatory cell death-PANoptosis in health and disease

Hyun Bae1, Yeonseo Jang1, Rajendra Karki2,3

  • 1Department of Biological Sciences, College of Natural Science, Seoul National University, Seoul, 08826, South Korea.

Archives of Pharmacal Research
|July 10, 2024
PubMed

Insights

PANoptosis, a novel regulated cell death (RCD) pathway, integrates pyroptosis, apoptosis, and necroptosis. Understanding this interplay is key for developing new treatments for infections, inflammation, and cancer.

Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Regulated cell death (RCD) pathways, including pyroptosis, apoptosis, and necroptosis, are vital for host defense and tissue homeostasis.
  • These distinct RCD pathways have been shown to interact and influence each other.
  • The emerging concept of PANoptosis highlights the complex interplay between these cell death modalities.

Purpose of the Study:

  • To provide a concise overview of PANoptosis, including its molecular mechanisms.
  • To explore the implications of PANoptosis in various disease contexts.
  • To emphasize the role of PANoptosis in infections, inflammatory diseases, and cancer.

Main Methods:

  • Literature review of genetic and pharmacological studies.
  • Analysis of molecular mechanisms underlying PANoptosis.
  • Examination of PANoptosis's role in disease pathogenesis.

Main Results:

  • PANoptosis represents an integrated form of regulated cell death involving pyroptosis, apoptosis, and necroptosis.
  • The interplay among RCD pathways is particularly evident during cellular responses to infections.
  • PANoptosis plays a significant role in cytokine storms, inflammatory conditions, and cancer development.

Conclusions:

  • Understanding the molecular mechanisms of PANoptosis is crucial for advancing therapeutic strategies.
  • Targeting PANoptosis may offer novel treatment avenues for infectious diseases, sterile inflammation, and cancer.
  • Further research into PANoptosis is warranted to fully elucidate its therapeutic potential.
Keywords:
ApoptosisCancerCell deathCytokine release syndromeInfectionInflammatory diseaseNecroptosisPANoptosisPyroptosis

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