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Updated: Jun 21, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Squamous cell carcinoma arising in a below-knee stump of a patient with chronic lymphocytic leukemia
Sarah Pender1, Alexander K Lu1, Sachinder S Hans2
1General Surgery Residency Program, Henry Ford Health, Clinton Township, MI.
Abstract:
We report a case of localized squamous cell carcinoma arising in the ulceration at the site of a below-knee amputation in a patient with chronic lymphocytic leukemia on treatment with ibrutinib. The patient underwent local excision of the skin and soft tissue with histopathology showing a small focus of well-differentiated squamous cell carcinoma in the specimen. This case highlights the importance of clinical evaluation and histopathological review for underlying malignancy in the setting of amputation stump ulceration.
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