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Matrix metalloproteinase inhibitors in restorative dentistry
I Perarivalan1, Janani Karunakaran1, Nathashri Anbalagan1
1Department of Conservative Dentistry and Endodontics, Chettinad Dental College and Research Institute, Kelambakkam, Tamil Nadu, India.
Abstract:
Matrix metalloproteinases (MMPs) have been identified as agents that disintegrate the collagen structures of dental hybrid layers, resulting in reduced restorative bond strength. Multiple MMP inhibitors (MMPIs) are known to counteract this degenerative mechanism, thereby preserving bond strength and promoting the longevity of resin-based restorations. Additionally, literature suggests that certain MMPI materials possess antimicrobial/anticariogenic properties, potentially reducing the risk of secondary caries development. Therefore, this review article aims to narrate on the integration of matrix metalloproteinase inhibitors into adhesive systems and their impact on bond strength.
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