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Ternary recognition fluorescent probe for lysosome acidification counter-ion studies via Cl-, K+, and pH
Guang-Yue Zou1, Fan Bi1, Shuai Chen1,2
1Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Box 332, Shenyang 110819, China. yuyl@mail.neu.edu.cn.
Abstract:
Lysosomal acidity relies on H+ inflow, which requires counter-ion flows (Cl- and K+) to balance charge. A lysosome targeting ternary recognition fluorescent probe for Cl-, K+, and pH was developed for lysosome acidification counter-ion research. The probe was used to study counter-ion changes when the Cl- channel was blocked and under oxidative pressure.
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