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Muscle mitochondrial function is impaired in adults with type 1 diabetes
Daniel Gottlieb1, Layla A Abushamat2, Kristen J Nadeau3
1NYU Langone Department of Pediatrics, New York City, NY, USA.
Journal of Diabetes and Its Complications
|July 11, 2024
Summary
Adults with type 1 diabetes exhibit in-vivo mitochondrial dysfunction, characterized by impaired oxidative capacity and efficiency. This suggests potential issues with substrate or oxygen delivery affecting mitochondrial health.
Area of Science:
- Endocrinology
- Metabolic Research
- Mitochondrial Biology
Background:
- Type 1 diabetes is linked to mitochondrial dysfunction, but mechanisms in adults are not fully understood.
- Previous studies indicated mitochondrial dysfunction in young individuals with type 1 diabetes.
Purpose of the Study:
- To investigate the in-vivo and ex-vivo mechanisms of mitochondrial dysfunction in adults with type 1 diabetes.
- To compare mitochondrial function between adults with type 1 diabetes and age-matched controls.
Main Methods:
- Secondary analysis of clinical trial data from adults with type 1 diabetes (n=34) and controls (n=59).
- In-vivo mitochondrial function assessed using 31P magnetic resonance spectroscopy during isometric exercise.
- Ex-vivo mitochondrial function evaluated through high-resolution respirometry of vastus lateralis muscle tissue.
Main Results:
- In-vivo analysis revealed higher anaerobic glycolysis and lower maximal mitochondrial oxidative capacity and efficiency in adults with type 1 diabetes.
- Adjusted analyses confirmed lower maximal mitochondrial capacity and higher anaerobic glycolysis in the type 1 diabetes group.
- Ex-vivo assessments did not show significant differences in mitochondrial function between groups.
Conclusions:
- In-vivo findings confirm mitochondrial dysfunction in adults with type 1 diabetes.
- The results suggest that impaired substrate or oxygen delivery may contribute to in-vivo mitochondrial dysfunction.
- This research extends previous findings in pediatric populations to adults with type 1 diabetes.
Keywords:
(31)phosphorous magnetic resonance spectroscopyHigh-resolution respirometryInsulin resistanceMitochondrial functionMuscleMore Related Videos
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