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Nanosuspension-Based Repaglinide Fast-Dissolving Buccal Film for Dissolution Enhancement
Hamsa Yaseen Ghadhban1, Kawther Khalid Ahmed2,3
1Al-Karkh Health Department, MOH, Ibn Al-Bitar Center for Cardiac Surgery, Baghdad, Iraq.
AAPS Pharmscitech
|July 11, 2024
Summary
Repaglinide (RPG) nanosuspension in buccal fast-dissolving films significantly enhances drug dissolution and permeation. Soluplus®-based nanoparticles achieved optimal particle size, improving RPG delivery compared to the pure drug.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Drug solubility and dissolution are critical challenges in pharmaceutical formulation development.
- Repaglinide (RPG) requires enhanced delivery strategies for improved therapeutic efficacy.
Purpose of the Study:
- To formulate and evaluate repaglinide (RPG) nanosuspension-based buccal fast-dissolving films (BDFs) for enhanced dissolution.
- To investigate the impact of various hydrophilic polymers on RPG nanosuspension characteristics and performance.
Main Methods:
- RPG nanosuspension prepared via antisolvent precipitation using polymers like Soluplus®, PVA, PVP, poloxamers, and HPMC.
- Nanosuspension incorporated into BDFs using solvent casting.
- Characterization included particle size, PDI, SEM, and FTIR.
- In vitro dissolution and ex vivo permeation studies conducted.
Main Results:
- Soluplus®-based nanosuspensions exhibited optimal particle size (82.6 nm) and spherical morphology.
- Nanosuspensions showed complete RPG release within 30 min, compared to 60% for pure RPG.
- Optimum BDFs demonstrated 28s disintegration time and 97.3% RPG release in 10 min.
- Ex vivo permeation studies showed significantly improved RPG flux (0.00275 mg/cm²/min) with nanosuspension films versus pure RPG (0.001058 mg/cm²/min).
Conclusions:
- RPG nanosuspension formulation using Soluplus® is effective for enhancing drug dissolution and buccal permeation.
- Buccal fast-dissolving films provide a viable platform for delivering RPG nanosuspensions.
- The developed formulation demonstrates superior performance compared to pure RPG, offering a promising approach for improved drug delivery.
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