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Updated: Jun 21, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Metal-free oxidative coupling of aryl acetylene with elemental sulphur and amines: facile access to α-ketothioamides
Deepika Sharma1, Rana Chatterjee1, Vasudevan Dhayalan2
1Department of Industrial and Engineering Chemistry, Institute of Chemical Technology, Indian Oil Odisha Campus, IIT Kharagpur Extension Centre, Mouza Samantapuri, Bhubaneswar-751013, Odisha, India.
Abstract:
A simple and efficient oxidative coupling of aromatic alkynes with elemental sulphur and secondary amines has been reported. The iodine/DMSO system easily promoted the transformations, affording thioglyoxamides via C-S, C-O, and C-N bond formations. In this context, acetylenic C-H bond oxidation has occurred through iodination, leading to the desired products. Moreover, this metal-free, one-pot protocol is accomplished by using readily available starting materials, without external oxidants, and under aerobic conditions, providing a variety of α-ketothioamide compounds in moderate to good yields.
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