Related Experiment Video
Updated: Jun 21, 2025

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
Published on: March 31, 2022
[The Russian priority in development of general intravenous anesthesia (Report II)]
S V Krylova1, N N Krylov2, I V Karpenko3
1The Humanitarian Institute of The Autonomous Non-Commercial Organization "The Russian New University", 105005, Moscow, Russia.
This study examines why Russian scientists' discovery of "Russian narcosis" using hedonal faced limited adoption. It identifies factors hindering its widespread use in Russia and internationally, impacting scientific recognition.
Area of Science:
- Medical History
- Pharmacology
- Anesthesiology
Background:
- N. P. Kravkov, a Russian scientist, developed "Russian narcosis" using hedonal.
- The adoption of this discovery faced significant obstacles.
- Historical context of Russian scientific contributions and international recognition.
Purpose of the Study:
- To evaluate the works of N. P. Kravkov and his contemporaries.
- To identify factors limiting the application of "Russian narcosis" both domestically and internationally.
- To explore the influence of German scientific recognition on Russian surgeons' self-esteem.
Main Methods:
- Historical analysis of scientific literature and correspondence.
- Evaluation of primary and secondary sources related to hedonal and "Russian narcosis".
- Examination of the socio-political and scientific environment of the late 19th and early 20th centuries.
Main Results:
- Several hidden and explicit, objective and subjective factors impeded the widespread application of hedonal.
- The discovery's potential was not fully realized due to these barriers.
- Russian surgeons' self-perception was significantly tied to validation from German scientific circles.
Conclusions:
- The limited dissemination of "Russian narcosis" was a complex issue influenced by multiple factors.
- Understanding these historical barriers provides insights into scientific progress and recognition.
- The study highlights the historical interplay between national scientific endeavors and international validation.
More Related Videos
Related Concept Videos
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Parenteral Anesthetics: Overview
Local Anesthetics: Clinical Application as Spinal Anesthesia
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

