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Detection of the pH-dependent Activity of Escherichia coli Chaperone HdeB In Vitro and In Vivo
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Co-chaperonin GroES subunit exchange as dependent on time, pH, protein concentration, and urea

Victor Marchenkov1, Alexey Surin2, Victor Ugarov1

  • 1Institute of Protein Research, Russian Academy of Sciences, 4 Institutskaya Street, 142290 Pushchino, Russia.

Biochimica Et Biophysica Acta. Proteins and Proteomics
|July 14, 2024
PubMed
Summary

Subunit exchange in oligomeric proteins like GroES heptamer (GroES7) is influenced by pH, concentration, and urea. Conditions that destabilize quaternary structure accelerate this exchange, impacting protein stability and function.

Keywords:
ElectrophoresisGroES co-chaperoninIsoelectric focusingStability of oligomeric proteinsSubunit exchange in oligomeric proteins

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