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Hybridoma Technology

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...

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Updated: Jun 21, 2025

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Microbe-material hybrids for therapeutic applications.

Meng Chen^1,2, Lili Xia¹, Chenyao Wu¹

¹Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China. fengw@shu.edu.cn.

Chemical Society Reviews

|July 15, 2024

Summary

Microbe-material hybrids leverage unique microbial properties for advanced nanomedicine. These living biomaterials offer enhanced drug delivery and therapeutic potential for various diseases.

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Area of Science:

Biomedical Engineering
Nanotechnology
Microbiology

Background:

Microorganisms are natural living substances utilized in medicine for creating microbe-material hybrids.
Engineering microbe-involved nanomedicine harnesses unique microbial physiological attributes, including hypoxia tendency and oxygen production.
These properties enable synergistic enhancements for improved drug delivery, site-specific therapy, and treatment monitoring.

Purpose of the Study:

To review microorganisms and microbial derivatives used in biomedicine.
To outline strategies for constructing microbe-material hybrids.
To illustrate diverse biomedical applications and discuss clinical translation challenges.

Main Methods:

Literature review of microorganisms and microbial derivatives in biomedicine.
Delineation of strategies and mechanisms for constructing microbe-material hybrids.
Exhaustive illustration of biomedical applications, including bioimaging and various therapies.

Main Results:

Microbe-material hybrids offer synergistic enhancements for therapeutic applications.
Diverse applications include bioimaging, anti-tumor, anti-bacterial, and anti-inflammatory therapies.
Microbe-material hybrids show promise for next-generation nanomedicine with theranostic properties.

Conclusions:

Microbe-material hybrids present substantial opportunities for amplifying disease treatment efficacy.
The unique versatility of these hybrids positions them as promising candidates for advanced nanomedicine.
Further research into clinical translation is needed to realize their full potential.