Association of Klotho with Neuropsychiatric Disorder: A Meta-Analysis

Area of Science:

• Neuroscience
• Gerontology
• Psychiatry

Background:

• Neuropsychiatric disorders manifest as behavioral, emotional, and cognitive symptoms.
• Klotho protein, an anti-aging factor, is implicated in cognitive changes associated with these disorders.

Purpose of the Study:

• To conduct a meta-analysis investigating the association between Klotho protein levels and various neuropsychiatric disorders.
• To compare Klotho levels across conditions including schizophrenia, bipolar disorder, Parkinson's disease, multiple sclerosis, depression, and Alzheimer's disease.

Main Methods:

• A systematic literature search was performed on PubMed using keywords like "Klotho" and specific neuropsychiatric disorders.
• Ten studies, selected from an initial pool of 82, were included in the meta-analysis.
• The Random effects model was employed to analyze the data, with forest plots used for cross-study comparison.

Main Results:

• Schizophrenia exhibited significantly higher Klotho protein levels compared to bipolar disorder, psychosocial stress, Parkinson's disease, multiple sclerosis, depression, Alzheimer's disease, and healthy controls.
• Multiple sclerosis also showed elevated Klotho levels.
• Bipolar disorder and Alzheimer's disease were associated with lower Klotho levels relative to schizophrenia.

Conclusions:

• The meta-analysis indicates a significant association between Klotho protein levels and schizophrenia.
• Results suggest differential roles of Klotho in various neuropsychiatric conditions.
• Further research is warranted to elucidate the biological functions of Klotho in psychiatric disorders.