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The Preparation of Chicken Ex Ovo Embryos and Chorioallantoic Membrane Vessels as In Vivo Model for Contrast-Enhanced Ultrasound Imaging and Microbubble-Mediated Drug Delivery Studies
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Lumen Pressure Modulation in Chicken Embryos.

Susannah B P McLaren1, Fengzhu Xiong2

  • 1Wellcome Trust/CRUK Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

Methods in Molecular Biology (Clifton, N.J.)
|July 15, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed a simple, cost-effective method to precisely control fluid pressure within developing organs. This technique is crucial for understanding embryonic development and organ formation.

Keywords:
BrainChicken embryoEpithelial organHydrostatic pressureLumen

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Area of Science:

  • Developmental biology
  • Biophysics
  • Organogenesis

Background:

  • Lumen pressure is vital for epithelial organ growth, morphogenesis, and patterning.
  • Existing methods for pressure modulation in developing embryos lack sensitivity and robustness for the required range (tens to hundreds of Pascals).

Purpose of the Study:

  • To describe a simple, cost-effective protocol for precise lumen pressure control in embryonic development.
  • To provide a method for detecting and varying pressure in the range of tens to hundreds of Pascals.

Main Methods:

  • Development of a pressure modulation apparatus.
  • Integration of a high-sensitivity pressure sensor.
  • Utilizing a finely tunable water column for pressure adjustment.

Main Results:

  • Demonstration of successful lumen pressure control in the developing brain of early chicken embryos.
  • Validation of the apparatus's ability to modulate pressure within the target range.

Conclusions:

  • The described apparatus offers a sensitive and robust solution for lumen pressure modulation in embryonic studies.
  • This cost-effective protocol facilitates research into the role of mechanical forces in organ development.