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Electrocochleography in Cochlear Implant Recipients: Correlating Maximum Response With Residual Hearing
Raphael R Andonie1,2, Wilhelm Wimmer2,3, Stephan Schraivogel1,2
1Hearing Research Laboratory, ARTORG Center for Biomedical Engineering Research, Bern University Hospital, University of Bern, Bern, Switzerland.
Ear and Hearing
|July 16, 2024
Summary
Objective electrocochleography (ECochG) analysis reveals a link between intraoperative cochlear microphonic (CM) amplitudes and residual hearing in cochlear implant patients. This method enhances ECochG
Area of Science:
- Oto-neurology
- Biomedical Engineering
- Auditory Neuroscience
Background:
- Electrocochleography (ECochG) is a valuable tool for assessing inner ear function in cochlear implant (CI) recipients.
- Current ECochG analysis often relies on subjective interpretation and lacks precise intracochlear measurement localization.
- Objective assessment of intraoperative cochlear microphonic (CM) amplitudes is needed to improve ECochG's utility.
Purpose of the Study:
- To objectively determine intraoperative CM amplitude patterns in CI patients.
- To correlate these CM amplitudes and their spatial distribution with preoperative residual hearing.
- To address limitations in current ECochG analysis by incorporating objective signal processing and intracochlear location.
Main Methods:
- A prospective study involving 31 CI patients undergoing intraoperative pure-tone ECochG after electrode insertion.
- Utilized an objective analysis method to identify maximum CM amplitude and corresponding electrode position.
- Computed tomography was used for electrode localization, determining tonotopic frequency and calculating tonotopic shift.
- Linear regression analysis assessed associations between CM amplitude, tonotopic shift, and preoperative hearing thresholds.
Main Results:
- CM amplitudes exhibited significant variability, ranging from -1.479 to 4.495 dBµV.
- A significant negative correlation was found between maximum CM amplitudes and preoperative hearing thresholds.
- A significant association was observed between tonotopic shift and preoperative hearing thresholds.
- Maximum CM amplitudes predominantly showed basal-directed tonotopic shifts.
Conclusions:
- Objective ECochG signal analysis combined with intracochlear localization enhances understanding of cochlear health.
- Established a clear link between intraoperative CM amplitudes, their spatial distribution, and preoperative hearing thresholds.
- Findings support automated ECochG analysis, potentially increasing its specificity as an objective biomarker for cochlear health.
