Ferroptosis-inducing photosensitizers alleviate hypoxia tumor microenvironment for enhanced fluorescence
Linhao Zhang1, Maomao He1, Xiang Xia1
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China. sunwen@dlut.edu.cn.
Chemical Communications (Cambridge, England)
|July 16, 2024
Abstract:
This study describes H2O2-activated photosensitizer nanoparticles (ICyHD NPs), which inhibit histone deacetylase via binding Zn2+ to induce ferroptosis and upregulate the intracellular O2, thus resulting in enhanced photodynamic therapeutic effect. ICyHD NPs exert strong antitumor effects on mice and have improved the therapeutic precision via observing the increase in cellular fluorescence.
