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Updated: Jun 21, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
08:43

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

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Transition Metal-Free Domino Hydroamination/Isomerization/Transamidation Sequence: An Entry to Trifluorinated

Dorian Schutz1, Clément Gommenginger1, Baptiste Moegle1

  • 1Equipe Synthèse Organique et Phytochimie, Institut de Chimie, CNRS-UdS, UMR 7177, 4 rue Blaise Pascal, CS 90032, 67081 Strasbourg, France.

The Journal of Organic Chemistry
|July 16, 2024
PubMed
Summary

A novel method synthesizes trifluorinated-5-methylenepyrrolidinone using ynamides and aldehydes. This process involves a two-carbon homologation followed by a metal-free domino reaction for stereoselective construction.

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