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Related Concept Videos

Riboswitches01:56

Riboswitches

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Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
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Transducer Mechanism: Enzyme-Linked Receptors01:27

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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
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Transducer Mechanism: G Protein–Coupled Receptors01:30

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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Ribozymes02:47

Ribozymes

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The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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G-protein Coupled Receptors01:21

G-protein Coupled Receptors

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Related Experiment Video

Updated: Jun 20, 2025

Preparation and Application of a New Bacterial Biosensor for the Presumptive Detection of Gunshot Residue
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Gas-sensing riboceptors.

Savani Anbalagan1

  • 1Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland.

RNA Biology
|July 17, 2024
PubMed
Summary

This study proposes novel RNA-based riboceptors for cellular gas sensing, expanding beyond traditional hemoprotein sensors. Investigating these riboceptors offers insights into the evolution of gas sensing and signaling pathways.

Area of Science:

  • Cellular biology
  • Molecular evolution
  • Biochemistry

Background:

  • Cellular gas sensing is crucial for life, preventing damage from reactive oxygen species.
  • Existing gas sensing mechanisms primarily rely on hemoprotein-based receptors.
  • The evolutionary conservation of gas sensing highlights its fundamental biological importance.

Purpose of the Study:

  • To propose RNA-based riboceptors as a novel class of gas sensors.
  • To explore non-heme metal ion or metal cluster-based riboceptor mechanisms.
  • To investigate the evolutionary origins of cellular gas sensing and gasocrine signaling.

Main Methods:

  • Literature review on existing gas sensing mechanisms.
  • Hypothesizing RNA-based G-quadruplex structures' potential for heme binding.
Keywords:
G-quadruplexGas sensingRNA-based receptorgasoreceptorshaemribozymeriboceptorgascorine signaling

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  • Conceptualizing non-heme metal ion/cluster interactions with RNA for gas sensing.

    • Main Results:

    • RNA G-quadruplex structures show potential for heme binding, suggesting riboceptor function.
    • Proposed novel mechanisms for metal ion/cluster-based RNA gas sensors.
    • Identified riboceptors as a potential key to understanding early cellular signaling.

    Conclusions:

    • RNA-based riboceptors represent a plausible alternative to hemoprotein gas sensors.
    • Further research into riboceptors can illuminate the evolution of gas sensing.
    • This work opens new avenues for studying cellular communication and signaling.