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Related Concept Videos

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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Transuterine Fetal Tracheal Occlusion Model in Mice
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Cardiac function in congenital diaphragmatic hernia.

Gabriel Altit1, Anie Lapointe2, Florian Kipfmueller3

  • 1Division of Neonatology, Montreal Children's Hospital, McGill University Health Centre, Montréal, Canada.

Seminars in Pediatric Surgery
|July 17, 2024
PubMed
Summary

Congenital diaphragmatic hernia (CDH) significantly impacts fetal and neonatal heart function, leading to ventricular dysfunction and pulmonary hypertension. This review details cardiac issues in CDH and offers management guidance.

Keywords:
CardiacCongenital diaphragmatic herniaEchocardiographyFetalHemodynamicNeonatalPulmonary hypertensionVentricular

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Area of Science:

  • Pediatric Cardiology
  • Neonatology
  • Congenital Abnormalities

Background:

  • Cardiac function is crucial in congenital diaphragmatic hernia (CDH) progression and patient outcomes.
  • Neonatal hearts in CDH patients may exhibit right and left ventricular dysfunction despite normal anatomy.

Purpose of the Study:

  • To explore abnormal fetal heart development in CDH.
  • To detail early postnatal cardiac dysfunction and its link to pulmonary hypertension.
  • To outline diagnostic and therapeutic strategies for CDH-related cardiac issues.

Main Methods:

  • Review of fetal and neonatal cardiac function in CDH.
  • Analysis of the interplay between cardiac dysfunction and pulmonary hypertension.
  • Discussion of echocardiographic assessment and clinical management.

Main Results:

  • CDH is associated with significant fetal and neonatal cardiac abnormalities.
  • Ventricular dysfunction and pulmonary hypertension are key pathophysiological components.
  • Effective management requires a comprehensive approach to cardiac support.

Conclusions:

  • Understanding cardiac involvement is vital for managing CDH patients.
  • Early diagnosis and intervention for cardiac dysfunction improve outcomes.
  • Multidisciplinary care is essential for optimizing the clinical course of CDH.