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Cell-adhesion molecule uvomorulin during kidney development.

D Vestweber, R Kemler, P Ekblom

    Developmental Biology
    |November 1, 1985
    PubMed
    Summary
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    Uvomorulin, a cell adhesion molecule, is expressed in developing kidney tubules but not glomeruli. Its appearance correlates with cell adhesion during kidney tubule formation.

    Area of Science:

    • Developmental Biology
    • Cell Biology
    • Molecular Biology

    Background:

    • Uvomorulin is a 120-kDa glycoprotein found on various epithelia.
    • Kidney morphogenesis involves the conversion of mesenchyme to epithelium upon induction.

    Purpose of the Study:

    • To investigate the expression pattern of uvomorulin during embryonic kidney development.
    • To determine the role of uvomorulin in kidney tubule and glomeruli formation.

    Main Methods:

    • Immunofluorescence and immunoblotting techniques were used to detect uvomorulin.
    • Antibodies against uvomorulin were applied to organ cultures of developing kidney tubules.

    Main Results:

    • Uvomorulin expression was absent in uninduced mesenchyme.

    Related Experiment Videos

  • Uvomorulin became detectable approximately 12 hours after induction, coinciding with cell adhesion.
  • Distinct expression patterns were observed: uvomorulin was present in developing tubules but absent in glomeruli.
  • Antibodies to uvomorulin did not disrupt kidney tubule histogenesis in organ culture.

    • Conclusions:

    • Uvomorulin likely plays a role in the initial adhesion of differentiating kidney tubule cells.
    • Despite its expression, uvomorulin's role in kidney histogenesis may be compensated or redundant, as antibody application did not inhibit development.