Electrical Responsive Coating with a Multilayered TiO₂-SnO₂-RuO₂ Heterostructure on Ti for Controlling Antibacterial...

Area of Science:

• Biomaterials Engineering
• Nanotechnology
• Orthopedic Surgery

Background:

• Bacterial infections and poor osseointegration hinder titanium (Ti) implant applications in bone repair.
• Developing advanced coatings is crucial for improving Ti implant performance.

Purpose of the Study:

• To engineer an electrically responsive TiO2-SnO2-RuO2 coating with a multilayered heterostructure for Ti implants.
• To investigate the coating's antibacterial and osteogenic properties, and its effect on osseointegration.

Main Methods:

• Fabrication of a multilayered TiO2-SnO2-RuO2 heterostructure coating on Ti implants.
• Utilizing the coating's band gap structure for response to endogenous electrical stimulation.
• Employing pseudocapacitance and redox reactions for surface modification and functional enhancement.
• In vivo experiments to evaluate antibacterial efficacy and osseointegration.

Main Results:

• The TiO2-SnO2-RuO2 coating exhibits electrical responsiveness due to its band gap structure.
• Postcharging induces redox reactions, enhancing antibacterial properties and osteogenesis-related gene expression in stem cells.
• Negatively charged SnO2@RuO2 promotes apatite deposition by attracting Ca2+.
• In vivo tests confirmed effective bacterial elimination and enhanced osseointegration with a synostosis bonding interface.

Conclusions:

• Negatively charging the electrically responsive TiO2-SnO2-RuO2 coating is an effective strategy.
• This approach significantly improves the antibacterial ability and osseointegration of modified Ti implants.