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Related Concept Videos

Psychosurgery01:30

Psychosurgery

52
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
52

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The Association Between Surgery and Mild Cognitive Impairment: Insight from a Case-Control Study.

Jian Yu1,2, Wenyu Tang1,2, Zubaidan Sulaiman2,3

  • 1Department of Psychiatry, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Journal of Alzheimer'S Disease : JAD
|July 20, 2024
PubMed
Summary

High-risk surgeries and procedures after age 75 increase the risk of developing mild cognitive impairment (MCI). This finding highlights the complex relationship between surgical interventions and cognitive health in older adults.

Keywords:
AgingAlzheimer’s diseaseelderlygeriatricmild cognitive impairmentsurgery

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Area of Science:

  • Gerontology
  • Neurology
  • Surgical Science

Background:

  • Postoperative cognitive impairment is a concern in elderly patients.
  • The specific link between surgery and mild cognitive impairment (MCI) requires further investigation.

Purpose of the Study:

  • To investigate the association between surgical procedures and the development of MCI in older adults.
  • To identify specific surgical factors, such as risk and timing, that may influence MCI development.

Main Methods:

  • Analysis of data from the Alzheimer's Disease Neuroimaging Initiative, including individuals with MCI and normal cognition.
  • Focus on surgeries performed after age 45, categorized by number, risk, and age at occurrence.
  • Utilized multivariable logistic regression to assess the relationship between surgery and MCI development.

Main Results:

  • No significant association was found between overall surgery exposure or the number of surgeries and MCI development.
  • High-risk surgeries were associated with an increased risk of developing MCI (adjusted OR = 1.79).
  • Surgeries performed after the age of 75 were also linked to a greater risk of MCI (adjusted OR = 2.01).

Conclusions:

  • High-risk surgeries and those performed at an older age (after 75) are associated with an increased risk of developing MCI.
  • These findings suggest complex mechanistic pathways contributing to postoperative cognitive impairment.