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Updated: Jun 20, 2025
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
The Association Between Surgery and Mild Cognitive Impairment: Insight from a Case-Control Study
Jian Yu1,2, Wenyu Tang1,2, Zubaidan Sulaiman2,3
1Department of Psychiatry, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Background:
Surgery may be associated with postoperative cognitive impairment in elder participants, yet the extent of its association with mild cognitive impairment (MCI) remains undetermined.
Objective:
To determine the relationship between surgery and MCI.
Methods:
The data of participants from the Alzheimer's Disease Neuroimaging Initiative were analyzed, including individuals with MCI or normal cognition. We focused on surgeries conducted after the age of 45, categorized by the number of surgeries, surgical risk, and the age at which surgeries occurred. Multivariable logistic regression was employed to determine the association between surgery and the development of MCI.
Results:
The study is comprised of 387 individuals with MCI and 578 cognitively normal individuals. The overall surgery exposure (adjusted OR = 1.14, [95% CI 0.83, 1.56], p = 0.43) and the number of surgeries (adjusted OR = 0.92 [0.62, 1.36], p = 0.67 for single exposure, adjusted OR = 1.12 [0.71, 1.78], p = 0.63 for two exposures, adjusted OR = 1.38 [0.95, 2.01], p = 0.09 for three or more exposures compared to no exposure as the reference) were not associated with the development of MCI. However, high-risk surgeries (adjusted OR = 1.79 [1.00, 3.21], p = 0.049) or surgeries occurring after the age of 75 (adjusted OR = 2.01 [1.03, 3.90], p = 0.041) were associated with a greater risk of developing MCI.
Conclusions:
High risk surgeries occurring at an older age contribute to the development of MCI, indicating a complex of mechanistic insights for the development of postoperative cognitive impairment.
Insights
High-risk surgeries and procedures after age 75 increase the risk of developing mild cognitive impairment (MCI). This finding highlights the complex relationship between surgical interventions and cognitive health in older adults.
Area of Science:
- Gerontology
- Neurology
- Surgical Science
Background:
- Postoperative cognitive impairment is a concern in elderly patients.
- The specific link between surgery and mild cognitive impairment (MCI) requires further investigation.
Purpose of the Study:
- To investigate the association between surgical procedures and the development of MCI in older adults.
- To identify specific surgical factors, such as risk and timing, that may influence MCI development.
Main Methods:
- Analysis of data from the Alzheimer's Disease Neuroimaging Initiative, including individuals with MCI and normal cognition.
- Focus on surgeries performed after age 45, categorized by number, risk, and age at occurrence.
- Utilized multivariable logistic regression to assess the relationship between surgery and MCI development.
Main Results:
- No significant association was found between overall surgery exposure or the number of surgeries and MCI development.
- High-risk surgeries were associated with an increased risk of developing MCI (adjusted OR = 1.79).
- Surgeries performed after the age of 75 were also linked to a greater risk of MCI (adjusted OR = 2.01).
Conclusions:
- High-risk surgeries and those performed at an older age (after 75) are associated with an increased risk of developing MCI.
- These findings suggest complex mechanistic pathways contributing to postoperative cognitive impairment.
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