Pathogenesis and treatment of immune-mediated renal disease

There is now convincing evidence to suggest that most forms of glomerulonephritis and tubulointerstitial nephropathy involve the immune system in the destructive process. Such involvement can be mediated by a humoral immune response, a cell-mediated immune response, or a coordinated response of both limbs of the immune system derived from complementary T- and B-cell interactions.