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Human disease-related long noncoding RNAs: Impact of ginsenosides
Siyeon Jang1, Hyeonjin Lee1, Hyeon Woo Kim1
1Department of Life Science, Dongguk University-Seoul, Goyang, Republic of Korea.
Journal of Ginseng Research
|July 22, 2024
Summary
Ginsenosides from ginseng regulate long noncoding RNAs (lncRNAs) to impact cancer cell activities. This review explores how ginsenosides and lncRNAs offer potential for cancer treatment and diagnostics.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Ginsenosides, active compounds in ginseng, possess antioxidant and anticancer properties.
- Long noncoding RNAs (lncRNAs) are crucial regulators of cancer cell functions like proliferation and metastasis.
- Ginsenosides exert therapeutic effects by modulating noncoding RNAs, including lncRNAs.
Purpose of the Study:
- To review the diverse activities of lncRNAs regulated by ginsenosides.
- To focus on the role of ginsenoside-regulated lncRNAs in target gene regulation via signaling pathways.
- To highlight the potential of lncRNAs as diagnostic markers in human diseases.
Main Methods:
- Literature review of studies on ginsenoside-induced lncRNA expression.
- Analysis of lncRNA involvement in cancer cell proliferation, apoptosis, metastasis, and autophagy.
- Examination of signaling pathways targeted by ginsenoside-regulated lncRNAs.
Main Results:
- Ginsenosides modulate lncRNA expression profiles to inhibit cancer cell proliferation.
- lncRNAs regulated by ginsenosides play roles in various cancer cell activities.
- lncRNAs are involved in complex regulatory networks with microRNAs and proteins.
Conclusions:
- Ginsenosides influence cancer progression through the regulation of lncRNAs.
- lncRNAs regulated by ginsenosides represent potential therapeutic targets and diagnostic biomarkers.
- Further research is needed to fully understand and utilize the potential of lncRNAs in cancer treatment.
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