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HLA-B*51:197: A composite product of interlocus recombination of B*51:01:01:01 and C*01:02:01:01

Niels Kouprie1, Laura B Bungener1, Annechien J A Lambeck1

  • 1Transplantation Immunology, Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

HLA
|July 23, 2024
PubMed

Insights

The novel HLA-B*51:197 allele was discovered. It arose from the recombination of two other HLA alleles, HLA-B*51:01:01:01 and HLA-C*01:02:01:01.

Area of Science:

  • Human leukocyte antigen (HLA) genetics
  • Molecular evolution
  • Immunogenetics

Background:

  • The human leukocyte antigen (HLA) system is crucial for immune response.
  • Allelic diversity within HLA genes is extensive.
  • Understanding HLA allele origins is vital for transplantation and disease association studies.

Purpose of the Study:

  • To characterize the origin of the novel HLA-B*51:197 allele.
  • To investigate the mechanism of its formation.

Main Methods:

  • Sequence analysis of HLA-B and HLA-C genes.
  • Comparative genomics to identify recombination events.

Main Results:

  • The HLA-B*51:197 allele was identified.
  • Sequence analysis confirmed it originated from interlocus recombination.
  • The recombination event involved HLA-B*51:01:01:01 and HLA-C*01:02:01:01.

Conclusions:

  • Interlocus recombination is a significant mechanism for generating novel HLA alleles.
  • This finding expands the known allelic repertoire of the HLA-B locus.
  • The discovery of HLA-B*51:197 provides new insights into HLA evolution.

Keywords:
HLA‐B*51:197recombinationsubmission number HWS10067759

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