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Exploring transcriptomic databases: unraveling circadian gene disruptions in lower grade glioma
Weiyu Hou1, Weiming Hou2, Xueming Zhao3
1Department of Neurosurgery, The First Hospital of Shanxi Medical University, Taiyuan, 030012, China.
Abstract:
The study explored the role of circadian rhythm genes (CRGs) in lower grade glioma (LGG) development and found that certain genes, such as CRY1, NPAS2, and RORB, were associated with increased or decreased risk of LGG. The study also investigated the correlation between CRGs and immune cell infiltration, revealing a negative association with macrophage infiltration and a positive correlation with B cell and CD8 + T cell infiltration. Additionally, the study identified major mutated CRGs, including PER2, BMAL1, CLOCK, and BMAL2, and their potential interaction with other CNS-associated genes. The study suggests that CRGs play a crucial role in immune response and tumorigenesis in LGG patients and warrants further investigation.
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