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Synthesis of β-Carbonyl α-Iminoamides by Double Insertion of Isocyanides into Aldehydes

Di Lu1, Shaohang Lu1, Chang-Hua Ding2

  • 1Department of Chemistry, Shanghai University, Shanghai 200444, People's Republic of China.

Organic Letters
|July 24, 2024
PubMed

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Primary amines react with carbonyl compounds—aldehydes and ketones—to generate imines. Imines consist of a C=N double bond and are named Schiff bases after its discoverer—the German chemist Hugo Schiff. On the other hand, secondary amines react with carbonyl compounds to give enamines. In enamines, the presence of a C=C double bond adjacent to the nitrogen atom leads to the delocalization of the lone pair.
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