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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Updated: Jun 19, 2025

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
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Cutaneous B-Cell Lymphomas.

Jennifer Villasenor-Park1, Jina Chung2, Ellen J Kim3

  • 1Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Perelman Center for Advanced Medicine, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

Hematology/Oncology Clinics of North America
|July 24, 2024
PubMed
Summary
This summary is machine-generated.

This review covers primary cutaneous B-cell lymphomas, a skin-specific non-Hodgkin's lymphoma. It details updated classifications, clinical features, and treatments for these conditions.

Keywords:
Cutaneous B-cell lymphomaEBV(+) mucocutaneous ulcerIVLBCLPCBCLPCDLBCL-leg typePCFCLPCMZL

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Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Primary cutaneous B-cell lymphomas (PCBCLs) are non-Hodgkin's lymphomas confined to the skin.
  • The 2018 WHO-EORTC classification defines key PCBCL subtypes.

Purpose of the Study:

  • To provide a comprehensive review of current literature on PCBCLs.
  • To update information on clinical presentation, pathology, genetics, prognosis, and treatment.

Main Methods:

  • Literature review of primary cutaneous B-cell lymphomas.
  • Analysis of updated classifications and research findings.

Main Results:

  • Detailed overview of PCBCL subtypes including marginal zone, follicle center, and diffuse large B-cell lymphomas.
  • Inclusion of provisional entity: EBV+ mucocutaneous ulcer.
  • Synthesis of data on clinical, histopathological, immunophenotypic, and genetic aspects.

Conclusions:

  • PCBCLs encompass a heterogeneous group of skin lymphomas.
  • Updated knowledge on diagnosis, prognosis, and management is crucial for patient care.