Gold-Catalyzed Lactone Synthesis: Advancements and Insights
D Ravi Sankar1, Mohan Neetha2, Gopinathan Anilkumar2,3
1Department of Chemistry, Sree Narayana College, Sreenivasapuram, Varkala, Kerala, INDIA, 695145.
Abstract:
Lactones represent a class of fundamental structural motifs ubiquitous in nature, holding significance across diverse scientific domains such as pharmaceuticals, natural products, drug discovery, and industry. Despite their simplicity, the synthesis of lactones has garnered considerable interest due to their pivotal roles. Gold, traditionally regarded as a noble metal, has emerged as an efficient catalyst, challenging conventional perceptions. The utilization of gold in lactone synthesis has captivated researchers, leading to the development of numerous effective methodologies. Motivated by this, we present a comprehensive compilation of reports on the gold-catalyzed synthesis of lactones, encompassing literature till date.
More Related Videos
06:31Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
Published on: November 27, 2015
07:36Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Related Concept Videos
α-Alkylation of Ketones via Enolate Ions
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Acid-Catalyzed α-Halogenation of Aldehydes and Ketones
In the first step of the mechanism, the acid protonates the carbonyl oxygen resulting in a resonance-stabilized cation, which subsequently loses an α-hydrogen to form an enol tautomer. The C=C bond in an enol is highly nucleophilic because of the electron-donating nature of the –OH group. Consequently, the double bond attacks an electrophilic halogen to form a...
Acid-Catalyzed Aldol Addition Reaction
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
