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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

31
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
31
Dissociative Identity Disorder01:30

Dissociative Identity Disorder

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Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...
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Related Experiment Video

Updated: Jun 19, 2025

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
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Sensorimotor Feedback Control Dysfunction as a Marker of Posttraumatic Stress Disorder.

Jonathon R Howlett1, Heekyeong Park2, Martin P Paulus3

  • 1VA San Diego Healthcare System, San Diego, California; Department of Psychiatry, University of California San Diego, La Jolla, California.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|July 25, 2024
PubMed
Summary

Individuals with posttraumatic stress disorder (PTSD) exhibit sensorimotor control deficits, specifically in drive (Kp) and damping (Kd) parameters. These findings highlight distinct control dysfunctions in PTSD compared to other psychiatric conditions.

Keywords:
Anxiety disordersComputational psychiatryControl theoryMotor controlPhasic arousalPosttraumatic stress disorder

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Control Systems Engineering

Background:

  • Posttraumatic stress disorder (PTSD) is linked to inhibitory control deficits across emotional, cognitive, and sensorimotor domains.
  • The rapid assessment of motor processing (RAMP) paradigm offers reliable measures of sensorimotor control.
  • This study investigates sensorimotor control in PTSD using the RAMP paradigm.

Purpose of the Study:

  • To investigate sensorimotor control deficits in individuals with PTSD.
  • To compare control performance in PTSD with healthy controls and a non-PTSD psychiatric group.
  • To identify specific control parameters affected in PTSD.

Main Methods:

  • Utilized the rapid assessment of motor processing (RAMP) paradigm.
  • Examined 40 individuals with PTSD, 40 with mood/anxiety disorders, and 40 healthy controls.
  • Estimated proportional-derivative control parameters: Kp (drive) and Kd (damping).

Main Results:

  • Individuals with PTSD showed significantly lower Kp (drive) compared to both healthy and mood/anxiety groups.
  • These differences in Kp persisted after controlling for color-word inhibition.
  • Kd (damping) significantly mediated the relationship between PTSD and Kp deficits, accounting for 96% of the effect.

Conclusions:

  • Dynamic control paradigms effectively reveal control dysfunctions in PTSD.
  • Specific psychiatric conditions may uniquely impact sensorimotor control subcomponents.
  • Findings suggest distinct sensorimotor control profiles across different psychiatric diagnoses.