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Photoluminescence: Applications

Photoluminescence: Applications

Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...

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Bioluminescent Bacterial Imaging In Vivo

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Published on: November 4, 2012

Bioluminescent Systems for Theranostic Applications.

Hyemin Kim¹, Seung Oh Jung¹, Seungchan Lee¹

¹Department of Cosmetics Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

International Journal of Molecular Sciences

|July 27, 2024

Summary

This summary is machine-generated.

Bioluminescence, light from living organisms, offers a safe internal light source for theranostics. Advances in protein engineering are expanding its use in bioimaging, biosensing, and therapy.

Keywords:

bioimaging bioluminescence biosensing luciferase optogenetics photodynamic therapy theranostics

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Area of Science:

Biochemistry
Biotechnology
Medical Applications

Background:

Bioluminescence, light emission from living organisms via luciferase enzymes, is a well-studied phenomenon.
Its internal light-generation capability makes it advantageous over external light sources for theranostic applications, overcoming penetration depth limitations.
Recent progress in protein engineering and delivery systems has broadened bioluminescence's utility.

Purpose of the Study:

To provide a comprehensive review of bioluminescence fundamentals.
To explore recent advancements and diverse applications of bioluminescence in theranostics.
To discuss future research directions for bioluminescent systems.

Main Methods:

Literature review of bioluminescence research.
Analysis of recent advancements in protein engineering and delivery platforms.
Synthesis of current applications in bioimaging, biosensing, photodynamic therapy, and optogenetics.

Main Results:

Bioluminescence serves as a safe and effective internal light source for theranostics.
Protein engineering and delivery platforms have significantly expanded bioluminescence applications.
Key applications include bioimaging, biosensing, photodynamic therapy, and optogenetics.

Conclusions:

Bioluminescence is a versatile tool with growing theranostic potential.
Continued advancements in protein engineering will further enhance its capabilities.
Future research should focus on optimizing bioluminescent systems for broader clinical translation.