Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Follow-up Strategies in Metabolic and Bariatric Surgery: Current strategies and Challenges.

Journal of metabolic and bariatric surgery·2026
Same author

Synergistic bone regeneration through sequential dual-drug delivery.

Biomedical engineering letters·2026
Same author

AI in Atomic Force Microscopy: Advancing Biological Nanoscale Imaging and Autonomous Discovery.

ACS nano·2026
Same author

Angelic Acid Disassembles Fibrillar α-Synuclein Aggregates through β-Sheet Interface Disruption.

ACS chemical neuroscience·2026
Same author

Citric acid disassembles α-synuclein fibrils and reduces their cytotoxicity.

Journal of pharmaceutical analysis·2026
Same author

Nanotrap-AI Integration Enables Ultra-Sensitive Point-of-Care HIV Testing.

ACS nano·2026

Related Experiment Video

Updated: Jun 18, 2025

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording
07:50

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording

Published on: October 29, 2021

2.6K

High-Porosity Sieve-Type Neural Electrodes for Motor Function Recovery and Nerve Signal Acquisition.

Wonsuk Choi1,2, HyungDal Park1, Seonghwan Oh1,2

  • 1Center for Bionics, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.

Micromachines
|July 27, 2024
PubMed
Summary

Higher porosity neural electrodes significantly improve nerve regeneration and motor function recovery in rats after sciatic nerve injury. This research highlights the importance of electrode design for better peripheral nerve repair outcomes.

Keywords:
Sciatic Function Index (SFI)electrode porositymotor function recoverynerve regenerationneural signal acquisitionsieve-type neural electrode

More Related Videos

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
09:35

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Published on: October 4, 2016

9.7K
The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

2.0K

Related Experiment Videos

Last Updated: Jun 18, 2025

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording
07:50

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording

Published on: October 29, 2021

2.6K
Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications
09:35

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Published on: October 4, 2016

9.7K
The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

2.0K

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Peripheral nerve injuries, such as sciatic nerve transection, often lead to significant functional deficits.
  • Current neural interface technologies face challenges in promoting effective nerve regeneration and signal acquisition.

Purpose of the Study:

  • To investigate the impact of electrode porosity on nerve regeneration and functional recovery following sciatic nerve transection in a rat model.
  • To compare the performance of sieve-type neural electrodes with different porosity levels (70% vs. 30%) for nerve repair and signal recording.

Main Methods:

  • Fabrication of sieve-type neural electrodes from photosensitive polyimide with 70% and 30% porosity.
  • Implantation of electrodes into transected rat sciatic nerves.
  • Evaluation of motor function recovery using the Sciatic Function Index.
  • Assessment of sensory neural signal acquisition (number of active channels, signal quality).
  • Electrode performance analysis using electrical impedance spectroscopy and immunohistochemistry.

Main Results:

  • The 70% porosity electrode group showed significantly enhanced nerve regeneration and motor function recovery, nearing control levels by week five.
  • The 30% porosity electrode group exhibited limited functional improvement.
  • Immunohistochemical analysis revealed extensive nerve fiber ingrowth within the 70% porous electrode structure.
  • The 70% porosity electrode consistently recorded neural signals from a greater number of channels with superior quality compared to the 30% electrode.

Conclusions:

  • Optimizing electrode porosity is crucial for developing advanced neural interfaces that promote nerve regeneration.
  • High-porosity electrodes (70%) demonstrate superior performance in both facilitating nerve repair and acquiring neural signals.
  • These findings have significant implications for improving clinical outcomes in peripheral nerve repair and neuroprosthetic applications.