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Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
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Can Hematological Inflammatory Indices Be Used to Differentiate Modic Type 1 Changes from Brucella Spondylodiscitis?
1Department of Sports Medicine, Medical Faculty, Van Yüzüncü Yıl University, Van 65090, Turkey.
Medicina (Kaunas, Lithuania)
|July 27, 2024
Summary
Hematological inflammatory indices (HII) do not effectively differentiate brucella spondylodiscitis from Modic type I changes (MC1). However, pain duration, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and platelet count can distinguish these conditions.
Area of Science:
- Medical Research
- Inflammation Studies
- Infectious Diseases
Background:
- Differentiating brucella spondylodiscitis from Modic type I changes (MC1) presents diagnostic challenges.
- Hematological inflammatory indices (HII), such as neutrophil-to-lymphocyte ratio (NLR) and aggregate index of systemic inflammation (AISI), are explored as potential markers for inflammation and infection.
Purpose of the Study:
- To evaluate the differences in HII between patients with brucella spondylodiscitis and MC1.
- To determine if HII can aid in distinguishing between infectious and non-infectious spinal inflammation.
Main Methods:
- A comparative study involving 35 patients with brucella spondylodiscitis and 37 with MC1.
- Diagnosis confirmed through microbiological, serological, and radiological methods.
- Calculation of various HII, including NLR, MLR, PLR, NLPR, SII, SIRI, and AISI, from complete blood counts.
Main Results:
- No significant differences were observed in HII (NLR, MLR, PLR, NLPR, SII, SIRI, AISI) between the two groups.
- Brucella spondylodiscitis patients exhibited shorter pain duration and higher CRP and ESR levels compared to MC1 patients.
- Platelet count was significantly lower in the brucella spondylodiscitis group than in the MC1 group.
Conclusions:
- HII may not be reliable indicators for differentiating infectious brucellosis from non-infectious MC1.
- Pain duration, CRP, ESR, and platelet count show potential as clinical indicators to distinguish brucella spondylodiscitis from MC1.
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