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Fecal Microbiota Characteristics in Constipation-Predominant and Mixed-Type Irritable Bowel Syndrome
Mariya Gryaznova1, Yuliya Smirnova1, Inna Burakova1
1Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia.
Microorganisms
|July 27, 2024
Summary
This study analyzed the gut microbiome in patients with Irritable Bowel Syndrome (IBS), finding altered bacterial diversity and specific microbial shifts. Several novel bacterial species were associated with IBS subtypes, offering new insights into the condition.
Area of Science:
- Microbiology
- Gastroenterology
- Human Health
Background:
- Irritable bowel syndrome (IBS) significantly impacts patient lifestyles.
- Gut microbiome alterations are linked to IBS, but mechanisms are unclear.
- This study focuses on the fecal microbiome in constipation-predominant IBS (IBS-C) and mixed-type IBS (IBS-M).
Purpose of the Study:
- To investigate the fecal microbiome composition in patients with IBS-C and IBS-M.
- To identify specific microbial changes associated with IBS subtypes.
- To explore potential microbial mechanisms underlying IBS.
Main Methods:
- Fecal samples from IBS patients and healthy controls were analyzed.
- The V3 region of 16S rRNA was sequenced using the Ion Torrent PGM platform.
- Microbiome composition and diversity were assessed.
Main Results:
- Increased alpha and beta diversity were observed in IBS-C and IBS-M patients compared to healthy individuals.
- Both IBS subtypes exhibited an elevated Firmicutes/Bacteroidetes ratio.
- Increased abundance of Actinobacteria and Verrucomicrobiota was noted in IBS patients.
Conclusions:
- This research is the first to associate specific bacteria, including *Turicibacter sanguinis* and *Parabacteroides merdae*, with IBS subtypes.
- Distinct microbial profiles were identified for IBS-C and IBS-M.
- These findings contribute to understanding the role of the gut microbiome in IBS pathogenesis.
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