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Update on Maintenance Immunosuppression in Intestinal Transplantation

Satyajit Patwardhan1, Julie Hong1, Joshua Weiner2

  • 1Columbia Center for Translational Immunology, 650 West 168th Street, BB1705, New York, NY 10032, USA.

Gastroenterology Clinics of North America
|July 27, 2024
PubMed

Outcomes in intestinal transplantation remain hampered by higher rates of rejection than any other solid organs. However, maintenance immunosuppression regimens have largely remained unchanged despite advances in therapies for induction and treatment of rejection and graft-versus-host disease. Recently, there have been a small number of new maintenance therapies attempted, and older agents have been used in new ways to achieve better outcomes. The authors herein review the traditional maintenance therapies and their mechanisms and then consider updates in new therapies and new ways of using old therapies for maintenance immunosuppression after intestinal transplantation.

Keywords:
Intestinal transplantationMaintenance immunosuppressionVedolizumab

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