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Excessive Daytime Napping Increases the Risk of Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and a Mendelian
Xiuqi Qiao1,2, Xiaoxia Wang1, Lixin Guo1,2
1Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People's Republic of China.
Daytime napping, especially longer naps over 30 minutes, is causally linked to a higher risk of developing non-alcoholic fatty liver disease (NAFLD). This finding holds true for both observational and genetic predispositions.
Area of Science:
- Hepatology and Genetic Epidemiology
Background:
- Observational studies suggest a link between daytime napping and non-alcoholic fatty liver disease (NAFLD).
- The causal relationship between daytime napping and NAFLD remains unclear.
Purpose of the Study:
- To investigate the causal relationship between daytime napping and non-alcoholic fatty liver disease (NAFLD).
- To synthesize evidence from genetic and observational studies.
Main Methods:
- A two-sample Mendelian randomization (MR) analysis using 105 single-nucleotide polymorphisms (SNPs) associated with daytime napping.
- Meta-analysis of observational data from the UK Biobank study on NAFLD outcomes.
- Network meta-analyses to assess the relationship between napping duration and NAFLD risk.
Main Results:
- Meta-analysis revealed a significantly higher risk of NAFLD for individuals napping over 30 minutes (OR = 1.32, 95% CI: 1.05 to 1.66).
- MR analysis indicated a genetic predisposition for longer daytime napping is significantly associated with increased NAFLD likelihood (OR = 2.26, 95% CI: 1.38 to 3.73).
Conclusions:
- Daytime napping, particularly durations exceeding 30 minutes, is causally associated with an elevated risk of non-alcoholic fatty liver disease (NAFLD).
- Findings support a direct causal link between habitual napping and NAFLD development.
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