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Causal Relationship Between Obstructive Sleep Apnea and Temporomandibular Disorders: A Bidirectional Mendelian
Yu-Pei Wang1, Hui-Xia Wei2, Yuan-Yuan Hu3
1Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People's Republic of China.
Nature and Science of Sleep
|July 30, 2024
Summary
Obstructive sleep apnea (OSA) causally influences temporomandibular disorders (TMD), suggesting a hereditary link. Early intervention is crucial for managing both conditions effectively.
Area of Science:
- Genetics
- Sleep Medicine
- Oral and Maxillofacial Surgery
Background:
- Obstructive sleep apnea (OSA) and temporomandibular disorders (TMD) are prevalent conditions.
- The etiological relationship between OSA and TMD remains incompletely understood.
Purpose of the Study:
- To investigate the potential bidirectional causal relationship between OSA and TMD.
- To explore the genetic underpinnings of the association between OSA and TMD.
Main Methods:
- Utilized a two-sample bi-directional Mendelian randomization (MR) approach.
- Employed inverse variance weighting as the primary analysis method, supplemented by MR-Egger, weighted median, simple mode, and weighted mode analyses.
- Assessed heterogeneity and validity using Cochran Q, MR-Egger, and MR-PRESSO tests.
Main Results:
- Forward MR analysis revealed a significant causal effect of OSA on TMD (OR=1.241, P=0.041).
- Reverse MR analysis showed no significant causal influence of TMD on OSA (IVW: OR=0.975, P=0.411).
Conclusions:
- Established a hereditary causative relationship where OSA influences TMD.
- Highlights the need for integrated prevention and treatment strategies for both OSA and TMD.
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