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A Novel Index System for Assessing Ventricular-Vascular Coupling.
Lingheng Wu1, Mengjiao Zhang2, Jianxiong Chen1
1Department of Ultrasound, Shanghai General Hospital of Nanjing Medical University, 200080 Shanghai, China.
View abstract on PubMed
A new ventricular-vascular coupling index (VVI) system, including arterial velocity pulse index (AVI) and left ventricular global longitudinal strain (LVGLS), effectively detects age-related cardiovascular changes. This novel system shows superior diagnostic performance compared to traditional indexes in various age groups.
Area of Science:
- Cardiovascular Physiology
- Echocardiography
- Biomedical Engineering
Background:
- Ventricular-vascular coupling (VVC) is crucial for cardiovascular health.
- Traditional VVC indices may not fully capture age-related functional changes.
- A novel VVI system comprising arterial velocity pulse index (AVI), left ventricular global longitudinal strain (LVGLS), and their ratio (AVI/LVGLS) was developed.
Purpose of the Study:
- To evaluate the utility of a novel VVI system in assessing cardiovascular function across different age groups, genders, and body mass index (BMI) categories.
- To compare the diagnostic performance of the novel VVI system with traditional VVC indices.
Main Methods:
- A cross-sectional study included 239 healthy volunteers stratified by age (young, middle-age, old), gender, and BMI.
Main Results:
- Middle-aged and elderly individuals exhibited higher Ea and lower LVGLS than younger subjects; AVI and AVI/LVGLS increased with age.
- Females showed higher Ea, Ees, and LVGLS than males, but AVI and AVI/LVGLS did not differ significantly between genders.
- The novel AVI/LVGLS index demonstrated superior diagnostic performance compared to traditional VVI and Ea in distinguishing cardiovascular function across age groups, particularly in younger and older cohorts.
Conclusions:
- The novel VVI system (AVI, LVGLS, AVI/LVGLS) effectively identifies age-related cardiovascular functional differences.
- This novel index system offers enhanced diagnostic capabilities for assessing ventricular-vascular coupling compared to traditional methods.
- The AVI/LVGLS ratio shows particular promise for evaluating cardiovascular health across the lifespan.


