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Updated: Jun 18, 2025
A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
Using Molecular Targets to Predict and Treat Aortic Aneurysms
Xiaonan Zhou1,2, Gang Liu1,2, Hao Lai1,2
1Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, 200032 Shanghai, China.
Abstract:
Aortic aneurysms are life-threatening vascular diseases associated with high morbidity, and usually require prophylactic surgical intervention. Current preventative management of aortic aneurysms relies on the diameter and other anatomic parameters of the aorta, but these have been demonstrated to be insufficient predictive factors of disease progression and potential complications. Studies on pathophysiology of aortic aneurysms could fill this need, which already indicated the significance of specific molecules in aortic aneurysms. These molecules provide more accurate prediction, and they also serve as therapeutic targets, some of which are in preclinical stage. In this review, we summarized the inadequacies and achievements of current clinical prediction standards, discussed the molecular targets in prediction and treatment, and especially emphasized the molecules that have shown potentials in early diagnosis, accurate risk assessment and target treatment of aortic aneurysm at early stage.
Insights
Aortic aneurysms require better prediction methods beyond size. Molecular targets show promise for early diagnosis, risk assessment, and treatment of this life-threatening vascular disease.
Area of Science:
- Vascular Biology
- Cardiovascular Medicine
- Molecular Medicine
Background:
- Aortic aneurysms are serious vascular conditions with high morbidity, often necessitating surgery.
- Current diagnostic standards based on aortic size are insufficient for predicting disease progression and complications.
- Understanding aneurysm pathophysiology is crucial for improved prediction and treatment strategies.
Purpose of the Study:
- To review current clinical prediction standards for aortic aneurysms.
- To discuss molecular targets for predicting and treating aortic aneurysms.
- To highlight molecules with potential for early diagnosis and risk stratification.
Main Methods:
- Literature review of current clinical prediction standards.
- Analysis of studies on aortic aneurysm pathophysiology.
- Identification and discussion of relevant molecular targets.
Main Results:
- Current methods using aortic diameter are inadequate predictors.
- Specific molecules are implicated in aneurysm development and progression.
- Several molecular targets show potential for early detection and risk assessment.
Conclusions:
- There is a critical need for improved prediction of aortic aneurysm progression.
- Molecular targets offer a promising avenue for enhanced diagnostic accuracy and risk stratification.
- Further research into molecular mechanisms can guide targeted therapies for aortic aneurysms.
